It is the summer of 1854 and a violent cholera outbreak has decimated the unseemly district of Soho, London. While the source of the outbreak remains unclear, the leading medical authorities blame the miasma, or poisonous air, which emanates from the filthy sewers and nearby bone boiling establishments. When an unlikely physician, Dr. John Snow, employs his newly developed disease mapping techniques, he uncovers an entirely different theory - that the outbreak is stemming from a public water source known as the Broad Street Pump. After his impulsive attempts to shut down the pump are thwarted by unknowing residents, he desperately seeks the aid of his medical colleagues. Snow’s outlandish theory is then ridiculed by the politically motivated and devout miasmist, Dr. Paris, who is charged by the Queen to put an end to the crisis. Snow realizes that he must face the Board of Governors alone, the only body that can authorize the closing of a local public utility. With the clock ticking and residents dying, he must piece together a scientific puzzle that will culminate in one historic moment, anointing Dr. John Snow as “Father of Modern Epidemiology”.